Metabolomics profiling provides valuable insights into the underlying mechanisms of Morinda officinalis on protecting glucocorticoid-induced osteoporosis
Xia T, Dong X, Lin L, Jiang Y, Ma X, Xin H, Zhang Q, Qin L · Journal of Pharmaceutical and Biomedical Analysis · 2019 March
DOI 10.1016/j.jpba.2019.01.019
Objective
To explore the protective effect of Morinda officinalis (MO) on glucocorticoid-induced osteoporosis (GIOP) modeled rats and osteoblasts, and elucidate the underlying mechanisms via UHPLC-Q-TOF/MS based metabolomics profiling.
Conclusions
These results suggested Morinda officinalis (MO) had a notable anti-glucocorticoid-induced osteoporosis (GIOP) effect, and the underlying mechanisms might be related to arachidonic acid metabolism.
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