Chinese Herbal Medicine for Chemotherapy-Induced Leukopenia: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials
Wang Q, Ye H, Wang Q, Li W, Yu B, Bai Y, Xu G · Frontiers in Pharmacology · 2021 May 04
DOI 10.3389/fphar.2021.573500
Objective
To assess the efficacy and safety of Chinese herbal medicine (CHM) for the treatment of chemotherapy-induced leukopenia (CIL).
Conclusions
Chinese herbal medicine (CHM) in combination with chemotherapy could effectively improve the clinical symptoms of chemotherapy-induced leukopenia (CIL) when compared with chemotherapy alone or Western medicine + chemotherapy, except when comparing with Placebo (PBO) + chemotherapy. While CHMs were generally safe for clinical use and exerted no severe side effects in the 14 RCTs, high-quality RCTs with larger sample sizes are essential to reduce study heterogeneity.
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