Systematic review and pathway enrichment analysis of Chinese medicine in preventing recurrence and improving prognosis of cholelithiasis after gallbladder-preserving lithotripsy
Li B, Lin Y, Nie B, Zhao G, Zhang X, Zhu M, Hu J, Huang P, Feng S, Qiu R, Tian G, Zhang S, Shang H · Annals of Palliative Medicine · 2021 December
DOI 10.21037/apm-20-1135
Objective
To explore the evidence for this view, we systematically reviewed the efficacy and safety of TCM for improving the prognosis of cholelithiasis after gallbladder-preserving lithotripsy and performed functional pathway enrichment analysis of TCM target genes.
Conclusions
Existing evidence suggests that the use of TCM may reduce the recurrence rate after gallbladder-preserving lithotripsy and this effect may be related to the flavonoid glycoside naringin from Glycyrrhiza uralensis, but more RCTs with high quality in this area may be needed to have a robust conclusion.
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Insights
Traditional Chinese Medicine shows promise in preventing cholelithiasis recurrence post lithotripsy
Traditional Chinese Medicine (TCM) may enhance prognosis for cholelithiasis patients following gallbladder-preserving lithotripsy. This systematic review analyzed TCM's efficacy and safety in this context, along with functional pathway enrichment analysis of TCM target genes. Nine randomized controlled trials (RCTs) involving 926 participants were included. Meta-analysis indicated TCM reduced cholelithiasis recurrence, complications, gallbladder wall thickness, and contraction degree. No significant adverse reactions were noted. The study suggested that TCM, particularly the flavonoid glycoside naringin from Glycyrrhiza uralensis, could be beneficial post-gallbladder-preserving lithotripsy, but further high-quality RCTs are needed for a conclusive assessment.
