Activation of Subcutaneous Mast Cells in Acupuncture Points Triggers Analgesia
Wang LN, Wang XZ, Li YJ, Li BR, Huang M, Wang XY, Grygorczyk R, Ding GH, Schwarz W · Cells · 2022 February 25
DOI 10.3390/cells11050809
Objective
This review summarizes experimental evidence indicating that subcutaneous mast cells are involved in the trigger mechanism of analgesia induced by acupuncture, a traditional oriental therapy, which has gradually become accepted worldwide.
Conclusions
The role of subcutaneous mast cells (MCs) in triggering acupuncture-induced analgesia, single steps in the signaling pathway still need further clarification. Similarly, the role of the release of serotonin and stimulation of 5-HT1 receptors in analgesia needs further investigation.
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