Saffron, derived from Crocus sativus flower, shows similar efficacy to antidepressant medications in treating major depression, potentially due to its variety of biochemical effects.
In the methodical study, electronic databases were consulted to find high-quality, randomized, double-blind studies that had either placebo or antidepressant controls. Six distinct studies were found through this process. In vivo and in vitro studies were reviewed to better comprehend the potential antidepressant mechanisms of action saffron brings forth.
The results showed that in the studies compared with a placebo, saffron had large beneficial effects. When compared with regular antidepressant medication, saffron demonstrated similar levels of efficacy. The potential mechanisms behind saffron's antidepressant qualities seemingly lay in its serotonergic, antioxidant, anti-inflammatory, neuro-endocrine, and neuroprotective effects.
