Exploring the mechanism of action of San Huang lotion for the topical treatment of eczema based on network pharmacology and molecular docking techniques

Wu C, Li WB, Liu Y, Yan XN · TMR Pharmacology Research · 2022 January

DOI 10.53388/PR202202009

Objective

To predict the mechanism of action of San Huang lotion for topical treatment of eczema at the level of network pharmacology and molecular docking technology.

Conclusions

The quercetin, luteolin, wogonin, formononetin, beta-sitosterol and other active ingredients in San Huang lotion may act on eczema through AKT1, TNF, IL6, IL1B, TP53, VEGFA and other targets, and through IL-17 signaling pathway, TNF signaling pathway, Th17 cell differentiation and other pathways.

Critical Appraisal

Published research can offer valuable insights, but a paper’s conclusions may go beyond what its results support. Critical appraisal examines the methods, findings and limitations to clarify what can reasonably be concluded—and what remains uncertain.

This article has not yet been critically appraised by the Research Hub.

Learn more about Critical Appraisal