Cellular stress response mechanisms of Rhizoma coptidis: a systematic review

Wang J, Ran Q, Zeng H, Wang L, Hu C, Huang Q · Chinese Medicine · 2018 June 07

Objective

Rhizoma coptidis has been used in China for thousands of years with the functions of heating dampness and purging fire detoxification. But the underlying molecular mechanisms of Rhizoma coptidis are still far from being fully elucidated. In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on cellular stress response pathways. Then we summarized the mechanisms of these alkaloid components of Rhizoma coptidis on cardiovascular and cerebrovascular diseases, diabetes and diabetic complications.

Conclusions

Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of cellular stress response pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches.

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