Mulberry leaf (Morus alba L.): A review of its potential influences in mechanisms of action on metabolic diseases
Zhang R, Zhang Q, Zhu S, Liu B, Liu F, Xu Y · Pharmacological Research · 2022 January
DOI 10.1016/j.phrs.2021.106029
Objective
The leaves of Morus alba L. (called Sangye in Chinese, ML), which belong to the genus Morus., are highly valuable edible plants in nutrients and nutraceuticals. In Asian countries including China, Japan and Korea, ML are widely used as functional foods including beverages, noodles and herbal tea because of its biological and nutritional value. In order to fully utilize and scale relevant products about ML, this review summarizes the up-to-date information about the ML and its constituents effecting on metabolic disease.
Conclusions
ML are widely used for lipid metabolism and sugar metabolism therapy in a multi-component and multitargeted manner. Overall, ML can be used for treating diabetes by reducing IR, protecting islet cells and regulating glucose-metabolism. For dyslipidemia, there are three strategies including (1) inhibiting fat synthesis and accelerate fat decompose (2) regulating cholesterol synthesis and consumption (3) modulating effects on the antioxidant system. In conclusion, ML as an auxiliary drug can prevent and cure MD. Not only does it reduce high-risk factors for MD, but also minimize the incidence of related complications.
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