Tianma Gouteng Decoction Exerts Pregnancy-Protective Effects Against Preeclampsia via Regulation of Oxidative Stress and NO Signaling
Jin M, Cao B, Lin C, Li J, Xu Q, Ren Q, Xu S, Tang C · Frontiers in Pharmacology · 2022 March 21
DOI 10.3389/fphar.2022.849074
Objective
Preeclampsia (PE), a pregnancy-specific syndrome with the major molecular determinants of placenta-borne oxidative stress and consequently impaired nitric oxide (NO) generation, has been considered to be one of the leading causes of maternal morbidity as well as mortality and preterm delivery worldwide. Several medical conditions have been found to be associated with increased PE risk, however, the treatment of PE remains unclear. Here, we report that Tianma Gouteng Decoction (TGD), which is used clinically for hypertension treatment, regulates oxidative stress and NO production in human extravillous trophoblast-derived TEV-1 cells.
Conclusions
TGD administration not only increased the weight gain during pregnancy and revealed a hypotensive effect, but also improved the placental weight gain and attenuated fetal growth restriction in an NG-nitro-L-arginine methyl ester (L-NAME)-induced mouse PE-like model. Our results thereby provide new insights into the role of TGD as a potentially novel treatment for PE.
Critical Appraisal
Published research can offer valuable insights, but a paper’s conclusions may go beyond what its results support. Critical appraisal examines the methods, findings and limitations to clarify what can reasonably be concluded—and what remains uncertain.
This article has not yet been critically appraised by the Research Hub.
Learn more about Critical Appraisal
Related insights
- Moderate consumption of beer, due to its melatonin content, can beneficially contribute to healthy diets and improve quality of life in certain physiological conditions.
- The active component in Tianma Gouteng Decoction, Gastrodin, offers protective effects against Preeclampsia by activating cellular signals while also suppressing harmful cell death.
- Saffron petal extract and anthocyanins can alleviate symptoms of Polycystic Ovary Syndrome by rectifying hormonal imbalances and reducing inflammation in PCOS mice.
- Kelulut honey, either alone or in combination with metformin or clomiphene, can alleviate oxidative stress and reproductive and metabolic abnormalities in rats with polycystic ovary syndrome.
- The date palm enhances both male and female fertility parameters through its nutritional attributes and antioxidant functionality.
- Green tea and its component EGCG, demonstrate potential as a treatment for endometriosis by inhibiting growth, invasion, adhesion and angiogenesis.
- The study shows the promising potential of Suan Zao Ren as a multi-effect traditional Chinese medicine derived from the seeds of Ziziphus Jujuba.
- Acupuncture was shown to significantly improve the sleep quality in pregnant women, possibly through increasing melatonin secretion.
