Mechanism of Salviae Miltiorrhizae Radix et Rhizoma in the Treatment of Knee Osteoarthritis Based on Network Pharmacology

Shi X, Zhang H, Hu Y, Li X, Yin S, Xing R, Zhang N, Mao J, Wang P · Natural Product Communications · 2020 December

DOI 10.1177/1934578X20983130

Objective

The molecular mechanism of Salviae Miltiorrhizae Radix et Rhizoma (SMRR) in the treatment of knee osteoarthritis (KOA) was analyzed based on network pharmacology.

Conclusions

Salviae Miltiorrhizae Radix et Rhizoma (SMRR) indirectly regulates IL-17, HIF-1, TNF, and other signal transduction pathways by regulating the expression of proteins, including PTGS2, MAPK1, EGFR, and CASP3, thus playing a role in promoting chondrocyte proliferation, improving microcirculation, eliminating free radicals, and inhibiting inflammatory factors.

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