Identification of Taohong Siwu Decoction in Treating Chronic Glomerulonephritis Using Network Pharmacology and Molecular Docking
Du G, Qu X, Hu J, Zhang Y, Cai Y · Natural Product Communications · 2022 November
DOI 10.1177/1934578X221139966
Objective
To explore the mechanism of action of Taohong Siwu Decoction (THSWD) in the treatment of chronic glomerulonephritis (CGN), with a view to finding the effective components of clinical prevention and treatment of CGN through research, and providing new research methods and therapeutic ideas for the treatment of CGN.
Conclusions
The molecular mechanism of Taohong Siwu Decoction (THSWD) in the treatment of chronic glomerulonephritis (CGN) from the perspective of network pharmacology are components such as beta-sitosterol, kaempferol, and quercetin and key action targets such as TNF, IL-6, AKT1 protein kinase, and MAPK14 protein kinase play a synergistic role in autoimmune, infection, and inflammatory response-related pathways.
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