Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Action of Huang Qin Decoction for Treament of Diabetic Liver Injury
Xu X, Fang C, Wang Y, Lu F, Liu S · Frontiers in Pharmacology · 2022 May 25
DOI 10.3389/fphar.2022.899043
Objective
Huang Qin Decoction (HQD), is used for the treatment of diabetic liver injury (DLI) and in this study, its mechanisms were evaluated by metabonomics and system pharmacology. This aims to study the anti-DLI effects of HQD.
Conclusions
The results demonstrate that the combination of metabolomics and network pharmacology could be used to reflect the effects of HQD on the biological network and metabolic state of DLI and to evaluate the drug efficacy of HQD and its related mechanisms.
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