Chinese medicine herb Bai Zhu might combat chronic gastritis by influencing inflammatory response, amino acid synthesis and energy metabolism.
Network pharmacology was employed to study the active ingredients, drug targets, and critical pathways of AMK in treating chronic gastritis. Initially, four databases were scoured to single out 77 candidate ingredients of AMK, reducing that to 27 active ingredients identified for CG treatment. Furthermore, 25 overlapping gene symbols linked to CG and drugs were procured from GeneCards and OMIM databases. The construction of a protein-protein interaction network and TCM comprehensive network followed this, resulting in 528 Gene Ontology terms and 26 pathways obtained through GO pathways and KEGG pathways enrichment analyses.
The investigation focused on the interleukin-17 signaling pathway, C-type lectin receptor signaling pathway, tumor necrosis factor signaling pathway, and AGE-RAGE signaling pathway in diabetic complications as crucial points and leading pathways for treating chronic gastritis. The study suggests that AMK potentially impacts the inflammatory response, amino acid synthesis, and energy metabolism. These influential active ingredients and targets have been experimentally validated for reliability, offering new insights into the systematic exploration of the traditional Chinese medicine mechanism of action.
