Metabolomic investigation into molecular mechanisms of a clinical herb prescription against metabolic syndrome by a systematic approach

Chen M, Yang F, Kang J, Gan H, Lai X, Gao Y · RSC Advances · 2017 January

Objective

Wendan decoction (WDD), a classic herb prescription in China, has been extensively proved to improve metabolic syndrome (Mets) in clinics. However, till now, its pharmacological mechanisms remained vague. In this study, a systematic approach that integrated GC-TOF/MS based metabolomics, multivariate statistical techniques (PCA and PLS-DA), KEGG pathway analysis and molecular docking simulation was established to explore the pathophysiological mechanisms of Mets and elucidate the molecular mechanisms of WDD against Mets rats.

Conclusions

Overall, this study provided an effective and comprehensive approach for understanding the pathophysiological mechanisms of Mets and therapeutic mechanisms of WDD in treatment of Mets.

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