Traditional uses, phytochemistry, pharmacology and toxicology of the genus Cimicifuga : A review
Guo Y, Yin T, Wang X, Zhang F, Pan G, Lv H, Wang X, Owoicho Orgah J, Zhu Y, Wu H · Journal of Ethnopharmacology · 2017 September
DOI 10.1016/j.jep.2017.07.040
Objective
This paper aims to provide up-to-date information on the genus Cimicifuga, including botanical characterization, medicinal resources, traditional medicinal uses, phytochemistry, quality control, pharmacological research as well as the toxicology. The possible structural-activity relationships and molecular mechanisms of the bioactive constituents are discussed in ways that contribute to the structural optimization and preclinical safety assessment for further drug design.
Conclusions
Modern pharmacology researchers have validated many traditional uses of Cimicifuga species. As the quality control and safety assessment of Cimicifuga plants is still incomplete, only a small part of the plant is permitted to be used as medicines. Expansion of medicinal resources in Cimicifuga is urgently needed to enable its full use. Extensive study is required on Cimicifuga plant before it can be fully used in clinics as a potent drug candidate.
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