Variants in clock genes could be associated with lower risk of type 2 diabetes in an elderly Greek population
Tsekmekidou X, Tsetsos F, Koufakis T, Georgitsi M, Papanas N, Papazoglou D, Roumeliotis A, Panagoutsos S, Thodis E, Theodoridis M, Passadakis P, Maltezos E, Paschou P, Kotsa K · Maturitas · 2021 October
DOI 10.1016/j.maturitas.2021.07.004
Objective
Recent evidence has linked circadian rhythm dysregulation to an increased risk of metabolic disorders. This study explores a potential association between variation in genes regulating the endogenous circadian timing system (clock genes) and the risk of type 2 diabetes (T2D) in a sample of Greek elderly people.
Conclusions
Our findings suggest a possible implication of clock genes in T2D susceptibility. Further studies are needed to clarify the mechanisms that connect circadian rhythm dysfunction and T2D pathogenesis.
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