Integrated metabolomics and network pharmacology approach to reveal immunomodulatory mechanisms of Yupingfeng granules
Li M, Gao Y, Yue X, Zhang B, Zhou H, Yuan C, Wu T · Journal of Pharmaceutical and Biomedical Analysis · 2021 February
DOI 10.1016/j.jpba.2020.113660
Objective
In this study, the underlying immunomodulatory mechanisms of yupingfeng granules (YPFG) were investigated based on the integration of metabolomics and network pharmacology methods.
Conclusions
YPFG influences the metabolism of bile acids and phospholipids. Flavonoids and saponins in YPFG were the main active components responsible for its immune-modulating effects. These components improved bile acid metabolism by enhancing the expression of certain proteins.
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