Self-assembled aggregations in Coptidis Rhizoma decoction dynamically regulate intestinal tissue permeability through Peyer's patch-associated immunity
Zhang Q, Yang Y, Ren R, Chen Q, Wu J, Zheng Y, Hou X, Zhang Y, Xue M, Yin D · Chinese Herbal Medicines · 2021 July
DOI 10.1016/j.chmed.2021.06.004
Objective
To investigate the dynamic regulation of self-assembled aggregations (SAA) in Coptidis Rhizoma decoction on the permeability of intestinal tissue and the mechanism underlying.
Conclusions
SAA can improve the Ber absorption in small intestine, through the PPs-associated immunity induced dynamic regulation on intestinal tissue permeability and TJ proteins expression. These findings might enlighten the research of traditional Chinese medicine decoction.
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