Traditional Chinese herbal medicine Astragalus Radix and its effects on intestinal absorption of aconite alkaloids in rats
Liang X, Ji M, Chen L, Liao Y, Kong X, Xu X, Liao Z, Wilson DW · Chinese Herbal Medicines · 2021 April
DOI 10.1016/j.chmed.2020.09.005
Objective
Many ancient texts record that they are not compatible using Astragali Radix and Aconite suggesting they can have negative outcomes when mixed. This study investigated whether Astragali Radix had either positive or negative effects on absorption of six different active alkaloids derived from aconite.
Conclusions
These results suggest that Astragali Radix can block absorption of aconite alkaloids through the upregulation expression of ATP-binding cassette transporters (ABC transporters) and tight junction proteins. It demonstrates that co-administration of Astragali Radix with other drugs might change the absorption profile of the second drug which is important to know in clinic therapy.
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