Characterization of the chemical constituents of Jie-Geng-Tang and the metabolites in the serums and lungs of mice after oral administration by LC-Q-TOF-MS
LIU YN, HU MT, QIAN J, WANG Y, WANG SF · Chinese Journal of Natural Medicines · 2021 April
DOI 10.1016/S1875-5364(21)60028-6
Objective
Jie-Geng-Tang (JGT), a traditional formula, is employed in the treatment of sore throat and cough. However, the potential effective constituents of JGT in vivo were still unclear. In this study, the chemical constituents of JGT were identified by liquid chromatography with quadrupole time-of-flight spectrometry (LC-Q-TOF-MS).
Conclusions
It was observed that three types of constituents, namely organic acids, flavonoids, and triterpene saponins, could be absorbed into the blood. Moreover, flavonoids and triterpene saponins were more likely distributed in the lung than in the blood.
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