Network pharmacology-based prediction of active compounds in the Wenyang Jiedu Huayu formula acting on acute-on-chronic liver failure with experimental support in vitro and in vivo
Tang D, Wang RY, Sun KW, Wu Y, Ding L, Mo Y · Frontiers in Pharmacology · 2022 October 20
DOI 10.3389/fphar.2022.1003479
Objective
This study aims to identify the active ingredients in WYJDHY and understand their mechanisms of action in treating ACLF. The effects of AT-1 on LPS-stimulated rat hepatocytes were investigated, and the involvement of NF-κB signaling was evaluated.
Conclusions
23 active ingredients of six herbs in the WYJDHY formula were retrieved, and 105 co-targets of drugs and disease were identified to be differentially expressed between ACLF and normal tissues. AT-1 protects against LPS-induced toxicity on hepatocytes, and the NF-κB pathway might be involved.
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