Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography–tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuan
Liu X, Li H, Wu L, Xing J, Poh Y, Cai H, Cai BC · Journal of Chromatography B · 2015 February
DOI 10.1016/j.jchromb.2014.11.025
Objective
The aim of this study is to develop a rapid, specific and sensitive ultra high performance liquid chromatography–triple quadrupole tandem mass method to simultaneously quantify chrysophanol and physcion in rat plasma, in order to better understand the pharmacokinetics and compatibility mechanism of Dahuang Fuzi Decoction for the first time.
Conclusions
Pharmacokinetic parameters showed significant difference between the two groups. The achieved comparative pharmacokinetic results were helpful to clarify the combination mechanism of Dahuang Fuzi Decoction.
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