Omega-3 Polyunsaturated Fatty Acids Suppress the Cystic Lesion Formation of Peritoneal Endometriosis in Transgenic Mouse Models

Tomio K, Kawana K, Taguchi A, Isobe Y, Iwamoto R, Yamashita A, Kojima S, Mori M, Nagamatsu T, Arimoto T, Oda K, Osuga Y, Taketani Y, Kang JX, Arai H, Arita M, Kozuma S, Fujii T · PLOS One · 2013 September 10

DOI 10.1371/journal.pone.0073085

Objective

To address the biological properties of omega-3 PUFAs in the homologous model of endometriosis in fat-1 mice.

Conclusions

In this study, we showed the suppressive effect of omega-3 PUFAs in the mouse endometriosis model by making full use of two types of genetically modified mice: fat-1 and 12/15-LOX KO mice.

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