Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice

Contreras-Bolívar V, García-Fontana B, García-Fontana C, Muñoz-Torres M · Nutrients · 2021 October 01

Objective

The aim of this review is to summarize the recent evidence linking vitamin D and insulin resistance and related disorders: obesity, T2D, MS, and PCOS. We also analyzed different interventional studies, including vitamin D supplementation, to evaluate its influence on these disorders.

Conclusions

A large body of findings on vitamin D and its association with disorders related to insulin resistance such as obesity, T2D, MS, and PCOS has been analyzed, with controversial results. Taken together, the results of basic and clinical studies reveal that vitamin D deficiency may be a key factor triggering the insulin resistance.

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Insights

Recent findings suggest that the molecular background to the development of insulin resistance may be related to vitamin D deficiency.

Taken together, the results of basic and clinical studies reveal that vitamin D deficiency may be a key factor triggering the insulin resistance. In this review, a large body of findings on vitamin D and its association with disorders related to insulin resistance such as obesity, T2D, MS, and PCOS has been analyzed, with controversial results.