Potential Role of Omega-3 Polyunsaturated Fatty Acids in Pediatric Food Allergy
Sartorio MUA, Pendezza E, Coppola S, Paparo L, D’Auria E, Zuccotti GV, Berni Canani R · Nutrients · 2021 December 29
DOI 10.3390/nu14010152
Objective
The review discusses the potential beneficial effects of polyunsaturated fatty acids (PUFAs) on pediatric food allergy prevention and treatment, focusing on omega-3 (ω-3) and omega-6 (ω-6) PUFAs.
Conclusions
Recent evidence suggests an imbalance in the ω-3:ω-6 ratio due to increased intake of ω-6, especially in westernized diets. The critical age groups, such as infants, toddlers, young children, pregnant/lactating women, and fish-allergic patients, may have inadequate ω-3 intake. Preclinical studies with PUFAs supplementation show promising effects in suppressing allergic responses, but clinical study results are conflicting regarding timing, dosages, and the most likely beneficiaries. The review emphasizes the need for more data on the effects of ω-3 PUFAs supplementation in both the general and food-allergic populations.
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