Role of omega‐6 and omega‐3 fatty acids in fetal programming
Shrestha N, Sleep SL, Cuffe JSM, Holland OJ, Perkins AV, Yau SY, McAinch AJ, Hryciw DH · Clinical and Experimental Pharmacology and Physiology · 2020 January 28
DOI 10.1111/1440-1681.13244
Objective
This review discusses the role of n-6 PUFA in fetal programming, the importance of a balance between n-6 and n-3 PUFAs in the maternal diet, and the need of further animal models and human studies that critically evaluate both n-6 and n-3 PUFA contents in diets.
Conclusions
Limited data have demonstrated that elevated n-6 FA can impair brain development and metabolic outcomes in adulthood. Despite the increasing number of studies demonstrating a detrimental role of elevated n-6 FA on off-spring health, the mechanisms underpinning these programmed outcomes are still poorly understood.
Critical Appraisal
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