Effect of traditional Chinese medicine formula GeGen decoction on primary dysmenorrhea: A randomized controlled trial study
Chai C, Hong F, Yan Y, Yang L, Zong H, Wang C, Liu Z, Yu B · Journal of Ethnopharmacology · 2020 October
DOI 10.1016/j.jep.2020.113053
Objective
To examine the efficacy and safety of GeGen Decoction, a well-known Chinese herbal formula, in treating primary dysmenorrhea by conducting a randomized, double-blinded, placebo-controlled trial and investigating its impact on pain intensity, serum levels of arginine vasopressin (AVP) and estrogen (E), and metabolomics in primary dysmenorrheic patients.
Conclusions
GeGen Decoction demonstrated a significant reduction in the severity of menstrual pain, as indicated by the visual analogue scale (VAS), without apparent adverse effects. The treatment influenced serum levels of AVP and E, suggesting a potential role in regulating pituitary-hypothalamic-ovarian hormones. Metabolomic analysis revealed distinct changes in seven important metabolites, further supporting the therapeutic effects of GeGen Decoction on primary dysmenorrhea.
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