Effect of Phenolic Compounds Extracted from Turmeric (Curcuma longa L.) and Ginger (Zingiber officinale) on Cutaneous Wound Healing in Wistar Rats

Bouchama C, Zinedine A, Rocha JM, Chadli N, El Ghadraoui L, Chabir R, Raoui SM, Errachidi F · Cosmetics · 2023 October 02

DOI 10.3390/cosmetics10050137

Objective

To investigate the effects of phenolic extracts from turmeric and ginger rhizomes on anti-inflammatory and healing properties.

Conclusions

The study concludes that the phenolic extracts from turmeric and ginger rhizomes have significant anti-inflammatory activity and promote wound healing.

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Insights

Phenolic extracts from turmeric and ginger have significant anti-inflammatory effects and enhance wound healing in Wistar rats.

The study utilised the solid-liquid extraction method to obtain phenolic extracts from turmeric and ginger rhizomes. Using Wistar rats as a biological model, the researchers examined the anti-inflammatory effects of the extracts by observing the decrease in edema volume in the rat's hind paw following treatment. Moreover, the healing process of purposefully induced burns on the rat's dorsal region was monitored to evaluate the healing activity. In the discussion of the results, it was observed that the application of creams containing the mentioned extracts resulted in complete healing after 19 days, a marked improvement compared to the control group, which only achieved 60% healing. The extracts demonstrated different levels regarding tissue repair at day 14, showing their respective potency. The study also identified diverse molecular weight distribution of phenolic compounds within the extracts, suggesting potential influence on how they affect anti-inflammatory and wound healing activities.