Conclusions
Bianliang ziyu flower ethanol extract (BZE) demonstrated hepatoprotective effects in APAP-induced rats by alleviating liver pathological changes, reducing serum AST and ALT levels, and exhibiting antioxidant and anti-apoptotic activities. BZE (440 mg/kg) significantly reduced ROS levels, upregulated SOD and GSH, activated p-AMPK, p-GSK3β, HO-1, and NQO1, promoted nuclear translocation of Nrf2, inhibited apoptosis through the PI3K–Akt pathway, and restored mitochondrial biogenesis, suggesting its potential as a liver-protecting agent.
