Ethanol and n-hexane extracts of Chrysanthemum indicum reveal potent anticancer activity against HepG2 cancer cells by promoting apoptosis and reducing cell proliferation.
The research methodology involved extracting compounds from Chrysanthemum indicum using ethanol and n-hexane. These extracts were then applied to HepG2 cancer cells. The study then carefully examined the effect on cell viability and proliferation, as well as indications of apoptosis, in the treated cells compared to untreated control cells. In addition to this, the antioxidative capabilities and antioxidative scavenging activity of the extracts were assessed, particularly focusing on their ability to neutralize nitric oxide, DPHH radicals, H2O2, and superoxide.
The results of this process demonstrated that both the ethanol and n-hexane extracts of Chrysanthemum indicum exhibited significant anticancer activity. This was evidenced by a marked decrease in cell viability and proliferation in the treated cancer cells, alongside an increase in indicators of apoptosis. Particularly, the ethanol extract showed more potent anticancer activity and antioxidative capability than the n-hexane extract. The treated cancer cells also showed greater antioxidative scavenging activity, further hinting at the antioxidant potential of these plant extracts.
