Chrysanthemum morifolium, Naringenin and Apigenin can alleviate depression-like behavior by interfering with specific metabolic pathways.
In this study, the researchers decided to evaluate the impact of Chrysanthemum morifolium, Naringenin, and Apigenin on depression-like behaviors instigated specifically by corticosterone. These substances, which are the primary active ingredients in the aqueous extract of C. morifolium and are used in Traditional Chinese Medicine, were analyzed regarding their therapeutic properties for depression. Researchers analyzed behavior and biochemical indicators tied to depression to understand the effects of these substances on a modeled depression scenario.
In the discussion of results, the authors highlight that these substances demonstrated antidepressant properties through their interference with certain metabolic pathways. These pathways include tryptophan metabolism, arginine and proline metabolism, citrate cycle, niacin and niacinamide metabolism, phenylalanine metabolism, and alanine, aspartate and glutamate metabolism. The effects were further explained on the basis of material and energy metabolism. Moreover, it was noted that Naringenin could potentially be used as a replacement for Chrysanthemum morifolium with similar beneficial outcomes; while Apigenin paralleled the function of other positive drugs targeting depression.
