The research explores the connection between Rheumatoid arthritis, a chronic inflammatory disease, and a set of comorbidities such as cardiovascular disorders, insulin resistance, metabolic syndrome, and sarcopenia, hypothesizing that these could possibly be associated with alterations in lipid metabolism. Patients with rheumatoid arthritis are observed to have lower cholesterol levels paradoxically coupled with an increased risk of cardiovascular disorders. The study also discusses the accumulation of toxic lipid mediators in skeletal muscles which can lead to mitochondrial dysfunctions and insulin resistance, both key factors of cardiovascular disorders and sarcopenia.

Through multiple research studies, it was observed that Omega 3 fatty acids could potentially inhibit the development of rheumatoid arthritis and improve muscle metabolism, consequently reducing muscle atrophy in patients with obesity and insulin resistance. Thus, dietary supplementation with Omega 3 fatty acids was suggested as a promising strategy to limit the lipotoxicity in muscles and prevent associated health risks in patients dealing with rheumatoid arthritis.