Uncovering the pharmacological mechanism of Shou Tai Wan on recurrent spontaneous abortion: A integrated pharmacology strategy-based research
Yang K, Zeng L, Li Y, Wu L, Xiang W, Wu X, Wang G, Bao T, Huang S, Yu R, Zhang G, Liu H · Journal of Ethnopharmacology · 2024 April
DOI 10.1016/j.jep.2023.117589
Objective
To investigate the pharmacological mechanism of Shou Tai Wan (STW), a traditional Chinese medicine formula, in the treatment of recurrent spontaneous abortion (RSA).
Conclusions
Shou Tai Wan (STW) was found to regulate PI3K/AKT, MAPK, and FoxO signaling pathways, and in animal experiments with an RSA mouse model, STW reduced embryo absorption rates, balanced Th1/Th2 cytokine expression, and demonstrated immunomodulatory effects by up-regulating the phosphorylation levels of STAT3 and STAT6 proteins and down-regulating STAT1 protein in the STAT signaling pathway. Additionally, STW up-regulated phosphorylation levels of proteins in the MAPK signaling pathway, and increased expression levels of ERK1/2 mRNA and proteins, suggesting potential therapeutic effects in treating RSA through interference with these signaling pathways.
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