Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity
Nash RJ, Bartholomew B, Penkova YB, Rotondo D, Yamasaka F, Stafford GP, Jenkinson SF, Fleet GWJ · ACS Omega · 2020 June 23
DOI 10.1021/acsomega.0c02092
Objective
To identify the active principle responsible for the anti-inflammatory activity in cucumbers, leading to the isolation of idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, an iminosugar amino acid from certain cucumbers, Cucumis sativus (Cucurbitaceae).
Conclusions
IdoBR1 demonstrated anti-inflammatory activity by reducing lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α) in THP-1 cells and ex vivo human blood. It selectively inhibited human α-l-iduronidase and sialidases from both bacteria (Tannerella forsythia) and human THP-1 cells. IdoBR1, along with cucumber extract, reduced the binding of hyaluronic acid (HA) to CD44 in LPS-stimulated THP-1 cells, suggesting its potential role as an anti-inflammatory agent by inhibiting induced sialidase involved in the production of functionally active HA adhesive CD44. Additionally, idoBR1 is excreted unchanged in urine following consumption, warranting further evaluation of its importance in the diet.
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