Inflammation modulation—targeting innate immune signals and exploring epigenetic regulation, the gut microbiome, and herbal agents—emerges as a promising treatment strategy for retinitis pigmentosa.
The study's methodology began by identifying and emphasizing the role of neuroinflammation in the progression of retinitis pigmentosa (RP). It delved into the effects of continuous sterile inflammation, caused by abnormal activation of immunity, which leads to neuron loss and structural destruction in RP. The main focus of the research was to review therapeutic strategies, concentrating on the modulation of innate immune signals like Tumor Necrosis Factor alpha (TNFα) signaling, Toll-Like Receptor (TLR) signaling, NLRP3 inflammasome activation, chemokine signaling, and Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signaling.
Post this initial evaluation, the study proceeded to explore novel therapeutic strategies. It examined how the pattern of gene activation and deactivation (epigenetic regulation), the gut microbiome (the collection of microbes living in our intestines), and various herbal agents can serve as possible treatment paths for retinitis pigmentosa.
