Patients with ulcerative colitis (UC) experienced greater clinical improvement and fewer adverse effects when treated with a combination of Traditional Chinese and Western medicine compared to Western medicine alone.
With an aim to assess the effectiveness and safety of combined Traditional Chinese and Western medicine (referred as ITCMWM hereafter) in treating ulcerative colitis, a systematic review was conducted following a registered protocol. Data was sourced from numerous databases including PubMed, Cochrane Library, Embase, the Chinese Biomedical Literature Database (CBM), the China National Knowledge Infrastructure (CNKI), and Wanfang Data. The review incorporated only randomized controlled trials comparing ITCMWM with stand-alone Western medicine. A total of 3957 patients from 38 studies, equally divided into the ITCMWM group and control group, were considered, and the risk ratios were calculated.
The results from the aggregated studies show that patients in the ITCMWM group reported a significantly better clinical outcome and witnessed fewer adverse events when compared to patients on stand-alone Western medicine. It was observed that the combination of both Traditional Chinese and Western treatments clearly outperformed Western medicine treatment alone in terms of overall effectiveness on ulcerative colitis. Additionally, the safety level was nearly equal for both treatment methods.
