Qing-Chang-Hua-Shi (QCHS) granules, a Chinese herbal formula, have shown significant efficacy in improving clinical remission and mucosal healing in moderately active ulcerative colitis patients.
The double-blind, randomized and placebo-controlled study was performed across multiple centers, involving patients with moderately active ulcerative colitis who had been unresponsive to mesalazine therapy for a month. The participants were randomly divided into groups, where one group received a daily dose of 125g QCHS granules along with continual 5-Aminosalicylate(5-ASA) therapy, and the other group received a placebo with the same color, taste and texture as QCHS granules, also with 5-ASA therapy.
The interpretation of the reported results revealed that both clinical remission and response were observed more substantially in the group treated with QCHS granules compared to the placebo group. Moreover, a higher rate of remission in mucus/bloody stools was seen in patients treated with QCHS granules versus the placebo. Overall, the adverse event rates did not significantly deviate between the QCHS granule and the placebo groups, indicating a similar level of safety for both treatments.
