Korean pear extracts appear to alleviate air pollution-related respiratory hypersensitivity by modulating beneficial gut microflora and suppressing pro-inflammatory cytokines.
In the preclinical and randomized double-blind clinical studies, mild-asthma subjects living in Seoul, Korea were divided into two groups: one receiving a daily treatment of pear extracts for four weeks, and a placebo group. The pear extract was tested for its ability to mitigate respiratory hypersensitivity connected to air pollution. The treatment's effects were evaluated based on the toxicokinetic study of exposure biomarkers for airborne polyaromatic hydrocarbons and levels of pro-inflammatory cytokines in human subjects.
In terms of results, it was found that those individuals receiving daily pear extract exhibited decreased levels of exposure biomarkers related to airborne polyaromatic hydrocarbons. Furthermore, the pear extract treatment was associated with a significant increase in populations of fiber-degrading bacteria that boost beneficial gut microflora crucial for immune defense. Additionally, the extracts significantly suppressed the production of various pro-inflammatory cytokines, as per the preclinical tests conducted on asthma-induced mice. Overall, these outcomes suggest a beneficial role of Korean pear extracts in mitigating air pollution-related respiratory hypersensitivity.
