Pomegranate fruit and its phytochemicals may offer a novel, natural alternative for the treatment of pathological anxiety, with fewer adverse effects than traditional medications.
Using a systematic review methodology, the researchers explored the potential anxiolytic (or anxiety-reducing) effects of pomegranate (PG) fruit and its natural compounds. Searches were conducted across numerous databases such as PubMed, ScienceDirect, Google Scholar, WorldWide Science, and Web of Science using specific predetermined terms. Only original articles meeting established inclusion criteria were chosen for review. The data collected from these articles provided information on the part and variety of pomegranates used, the species studied, sample size, anxiety model, dose, route and time of administration, reference drug, main results, and associated mechanisms of action.
The review of 59 such studies revealed PG as well as compounds it contains - specifically anthocyanins, flavonoids, tannins, organic acids, and xanthonoids - as having potential anxiolytic effects. According to the existing literature, these effects appear to be driven by several molecular mechanisms. These include the inhibition of specific anxiety-linked receptors, activation of certain cellular pathways associated with anxiety reduction and resilience, modulation of inflammatory proteins, and reduction of oxidative stress. The results position pomegranate and its phytochemicals as a potentially new natural option for the treatment of anxiety disorders. This is the first review to focus on the anxiolytic impact of pomegranates.
