Oral administration of Lactobacillus acidophilus 6074 fermented jujube juice can improve gut microbiota, alleviate intestinal inflammation, and reduce colon damage in mice.
The study used jujube juice as the substrate fermented by L. acidophilus 6074 to observe its effects on gut microbiota, intestinal barrier function, oxidative stress, and inflammatory factors in mice with colitis. The process of fermentation caused significant changes in the compounds of the juice, particularly in organic acids and free amino acids. A high dose of the juice demonstrated significant improvements in overall colitis markers, including the physical condition of the colon and disease activity.
Upon administering the fermented jujube juice, it was observed that the treatment promoted the reinforcement of the colonic mucosal barrier, boosting the expression of various tight junction proteins. Moreover, it inhibited the production of proinflammatory factors and reduced oxidative stress, thereby mitigating colon damage. The gut microbiota composition shifted as a result, demonstrating an increase in beneficial bacteria, a boost in short-chain fatty acids, and a reduction in harmful microorganisms. These findings indicate that the fermented juice can restore the balance in gut microbiota altered by intestinal inflammation and lessen the impact of colitis.
