Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial
Ruggenenti P, Caruso MR, Cortinovis M, Perna A, Peracchi T, Giuliano GA, Rota S, Brambilla P, Invernici G, Villa D, Diadei O, Trillini M, Natali G, Remuzzi G · EClinicalMedicine · 2022 January
DOI 10.1016/j.eclinm.2021.101227
Objective
To investigate the effects of fresh lemon juice supplementation on time to stone recurrence in patients with recurrent idiopathic calcium oxalate nephrolithiasis who were all prescribed a standard diet.
Conclusions
Fresh lemon juice supplementation, in addition to a standard diet, may potentially prevent stone recurrence in patients with calcium-oxalate nephrolithiasis, with explorative analyses showing a significant reduction in recurrence at one-year follow-up. However, decreasing adherence to lemon juice supplementation over time may reduce its efficacy.
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