Broccoli Sprouts and Their Influence on Thyroid Function in Different In Vitro and In Vivo Models
Paśko P, Zagrodzki P, Okoń K, Prochownik E, Krośniak M, Galanty A · Plants · 2022 October 18
DOI 10.3390/plants11202750
Objective
To investigate the safety and potential beneficial effects of broccoli sprouts on thyroid function in both in vitro and in vivo models.
Conclusions
Broccoli sprouts decreased the viability of thyroid cancer cells, prevented inflammation, and showed a satisfactory safety profile in both in vitro and in vivo experiments.
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Insights
Broccoli sprouts may reduce the viability of thyroid cancer cells and prevent inflammation, demonstrating a promising safety profile for normal thyroid function.
The methodology of the study involved two models - in vitro and in vivo. The in vitro model involved evaluating the impact of broccoli sprouts on normal and neoplastic thyroid cells and determining their anti-inflammatory and antioxidant potentials in macrophages. The in vivo model involved analyzing the thyroid glands of healthy and hypothyroid rats (induced by iodine deficiency or sulfadimethoxine ingestion) that were fed with broccoli sprouts.
The results of the study showed that broccoli sprouts effectively decreased the viability of thyroid cancer cells and forestalled inflammation. Further, regardless of the condition in vitro and in vivo, the results confirmed a satisfactory safety profile of broccoli sprouts. The research concluded that understanding the influence of brassica vegetables like broccoli sprouts on thyroid function carries significant public health implications considering the increasing risk of iodine deficiency, hypothyroidism, and thyroid cancer worldwide.
