The Suanzaoren decoction can potentially treat Parkinson's disease with sleep disorder through its multicomponent, multitarget, and multipathway characteristics, with key active components being quercetin and kaempferol.
The study used a network pharmacology and molecular docking approach to explore the action of the Suanzaoren decoction (a traditional Chinese medicine) for Parkinson's disease with sleep disorder. Bioactive components and targets of the decoction were identified using Traditional Chinese Medicine Systems Pharmacology and standardized on the UniProt platform. Data about Parkinson's disease and Sleep disorder were collected from various databases creating a protein-protein interaction network with the STRING platform and Cytoscape software. Gene Ontology enrichment analysis and pathway analysis were then conducted using the DAVID platform and Cytoscape software. The key active ingredients and action targets of the drug were verified using molecular docking.
The study found 135 Chinese herbal components and 41 corresponding targets useful for treating Parkinson's disease with sleep disorder using the decoction. The researchers identified 15 important signaling pathways, including the cancer pathway, TNF signaling pathway, PI3K-AKT signaling pathway, HIF-1 signaling pathway, and the Toll-like receptor signaling pathway. The main active compounds exhibited good affinity while binding to the representative targets, implying high effectiveness. These findings provide a detailed understanding of the Suanzaoren decoction's mechanisms at a molecular level, confirming its usefulness in treating Parkinson's disease with sleep disorder.
