Tianmagouteng particles (TMGTP) could mitigate cognitive dysfunction in spontaneously hypertensive rats, potentially by altering glucose metabolism in different brain regions.
The research involved sixteen spontaneously hypertensive rats with hyperactivity of liver-yang, divided into a treatment group and a non-treatment group. To induce hyperactivity of liver-yang, the rats were fed aconite decoction. After the rat models were prepared, the treatment group was given TMGTP once daily for 14 days, while the non-treatment or control group received an equivalent volume of saline. The cognitive function of the rats was observed using the Morris water maze test, both before and after the treatment period. Following the treatment, brain activity was visualized using Fluorine 18-deoxy glucose PET scans.
The results indicated that the escape latency was significantly lower, and the frequency of entering the target zone was significantly higher in the treatment group when compared to the non-treated group. Moreover, the TMGTP also influenced brain activity, inducing activity in several brain regions including the dorsolateral nucleus, ventrolateral nucleus of thalamus, amygdala, cerebellum leaflets among others but led to the deactivation of certain areas like the medial frontal gyrus, corpus callosum, hippocampus, and dentate gyrus. However, more research is needed to fully understand the implications and potential applications of these findings.
