Omega-3 polyunsaturated fatty acids, found in small oily fish, may help protect against inflammation and autoimmunity within the thyroid, notably Hashimoto's thyroiditis.
The study discusses the effects of omega-3 polyunsaturated fatty acids (PUFA) predominantly found in small oily fish such as anchovies and sardines. It focuses on the interaction between omega-3 PUFA and thyroid hormones, including the latter's transport proteins. One of the key mechanisms involved in autoimmunity protection offered by omega-3 PUFA is the decreased production of chemokines, similar to how other nutraceuticals work. Recent studies indicate that resolvins, which increase intracellularly, are also involved. These resolvins are associated with tissue protection against inflammation, which has been observed in experimental animals administered with both omega-3 PUFA and thyroid hormone.
The research also evaluates the market dynamics of omega-3 products, noting that fish oils – primarily derived from anchovies – are considered as the safest and most effective source of omega-3. Given the anti-autoimmunity and anti-cancer properties of omega-3 PUFA, there is a significant rationale for their role in countering Hashimoto's thyroiditis and correcting serum TSH levels in subclinical hypothyroidism. This pertaining to the increasing incidence of thyroid-related conditions globally, as well as the inherent risk of developing metabolic and cardiovascular disorders due to elevated or fluctuating serum TSH levels and thyroid autoimmunity.
