Neuropeptide Initiated Mast Cell Activation by Transcutaneous Electrical Acupoint Stimulation of Acupoint LI4 in Rats
Chen LZ, Kan Y, Zhang ZY, Wang YL, Zhang XN, Wang XY, He W, Jing XH · Scientific Reports · 2018 September 17
DOI 10.1038/s41598-018-32048-3
Objective
To investigate the local response and underlying mechanism of transcutaneous electrical acupoint stimulation at the Hegu acupoint.
Conclusions
Transcutaneous electrical acupoint stimulation induced sensory nerve fibres to express calcitonin gene-related peptide and substance P, which activated neurokinin-1 receptors on mast cells and caused mast cell degranulation with serotonin release, generating acupuncture-like signals.
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