Sulforaphene identified from radish (Raphanus sativus L.) seeds possesses antimicrobial properties against multidrug-resistant bacteria and methicillin-resistant Staphylococcus aureus
Sooyeon Li, Sang-Wook Han, Jongkee Kim · Journal of Functional Foods · 2016 June
DOI 10.1016/j.jff.2016.04.005
Objective
Aim to optimised and improved SFE extraction method using preparative liquid chromatography, and demonstrated that SFE possesses broad antimicrobial activity.
Conclusions
Radish seeds highlighted the highest antimicrobial property against multidrug-resistant Helicobacter pylori 212 strain.
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Insights
Strong bactericidal activity was exhibited by sulforaphene against all strains of Helicobacter pylori.
Sulforaphene (SFE), one of the major ITCs in radish seeds, specifically exhibited a strong effect against the multidrug-resistant H. pylori strain 212 with a MIC90 (0.6 µg/mL). Methicillin-resistant Staphylococcus aureus was also susceptible to SFE treatment, with MIC90 values of 12.5–25.0 µg/mL, but not methicillin-susceptible S. aureus. This observation gives new insight into the potential of SFE as a medicinal resource in foods and has implications in the development of new functional antimicrobial agents.
