Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation
Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P · Nutrients · 2018 October 23
DOI 10.3390/nu10111564
Objective
To provides an integrated review of how glutamine metabolism in key organs is important to cells of the immune system.
Conclusions
Immune cells largely depend on glutamine availability to survive, proliferate, and function, and ultimately defend our body against pathogens. During catabolic/hypercatabolic circumstances, the demand for glutamine increases dramatically, a fact that may lead to a glutamine deprivation and severe impairment of the immune function. It is important to consider that like glycaemia, plasma glutamine and the inter-tissue metabolic flux is maintained at constant levels even during high catabolism by key organs, such as the gut, liver, and skeletal muscles.
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