Avocado Seed

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Chinese Medicine Research Hub

Animal Study

Persea americana seed extract can counteract the negative effects of cyclosporine on male rat reproduction, enhancing antioxidant enzyme activity, sperm quality, and hormonal balance.

2022 Journal of Food Biochemistry Persea americana seed extract restores defective sperm quality and biochemical parameters relevant to reproduction in male wistar rats treated with cyclosporine A
Adebayo AA, Babatola LJ, Fasanya CB, Oboh G

Chinese Medicine Research Hub

Experimental Study

The ethanol extract of avocado seeds demonstrates an anti-endometriosis effect, potentially providing a new alternative treatment for endometriosis.

2020 Evidence-Based Complementary and Alternative Medicine The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis
Minko Essono S, Mvondo MA, Ngadjui E, Kemka Nguimatio FX, Watcho P

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Avocado Seed" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Avocado Seed" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Avocado Seed" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Animal Study published in 2022 in the journal Journal of Food Biochemistry found that Persea americana seed extract can counteract the negative effects of cyclosporine on male rat reproduction, enhancing antioxidant enzyme activity, sperm quality, and hormonal balance. Thirty male albino rats were used in this experiment and, apart from the control group, all were induced with cyclosporine. They were then divided into five groups: one remained untreated, the second was given lisinopril, and the remaining two received varying doses of Persea americana seed extract (PAE). The antioxidant enzymes, superoxide dismutase and catalase, along with arginase activities, nitric oxide, and malondialdehyde levels of the penile tissue, were evaluated. Additionally, serum hormonal concentration (including follicle stimulating hormone, luteinizing hormone, and testosterone) and sperm quality were examined. In cyclosporine-induced rats, there was a notable decline in antioxidant enzymes, sperm quality, nitric oxide, and hormonal levels. More so, arginase activity and malondialdehyde levels increased. However, once groups were treated with PAE or lisinopril, a significant improvement was observed across these parameters, including a decrease in malondialdehyde levels and arginase activity. This demonstrates that the persea americana seed extract possesses therapeutic potential for managing hormonal disruptions caused by oxidative stress.

A Experimental Study published in 2020 in the journal Evidence-Based Complementary and Alternative Medicine found that The ethanol extract of avocado seeds demonstrates an anti-endometriosis effect, potentially providing a new alternative treatment for endometriosis. Methodology: The study involved inducing endometriosis in female Wistar rats by grafting uterine fragments onto their peritoneum. Upon successful transplantation, these rats were orally treated with differing doses of an ethanol extract from Lauraceae seeds over a span of 7 days. Key benchmark measures included endometrial implant volume, as well as serum and lesion estradiol and progesterone levels. The study also analyzed the oxidative status of endometriosis lesions and carried out histological analysis of the lesions, uterus, and ovaries. Discussion of Results: The treatment with the ethanol extract of Lauraceae seeds resulted in a decrease in endometrial implant volume and a reduction in both serum levels and lesion levels of estradiol and progesterone. The oxidative status reflected an increased presence of key antioxidants in the endometriosis lesions. Histologically, the endometrium height was reduced, with an increase in the number of antral follicles and corpora lutea, alongside a decrease in luteinized unruptured follicles. Therefore, the study concluded the ethanol extract displayed a pronounced antiendometriosis effect.

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