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2020 Experimental Eye Research
Experimental Study Retinitis Pigmentosa
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Chinese Medicine Research Hub
Experimental Study
Gypenosides, the main functional component from the vine Gynostemma pentaphyllum, display potential as a treatment for Retinitis Pigmentosa by protecting photoreceptor cells from degeneration.
2020 Experimental Eye Research Gypenosides attenuate retinal degeneration in a zebrafish retinitis pigmentosa model
Alhasani RH, Zhou X, Biswas L, Li X, Reilly J, Zeng Z, Shu X
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Jiao Gu Lan" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Jiao Gu Lan" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Jiao Gu Lan" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Experimental Study published in 2020 in the journal Experimental Eye Research found that Gypenosides, the main functional component from the vine Gynostemma pentaphyllum, display potential as a treatment for Retinitis Pigmentosa by protecting photoreceptor cells from degeneration. In this study, researchers used zebrafish carrying a specific mutation that leads to early retinal degeneration like in Retinitis Pigmentosa, a group of genetic retinal disorders. The mutation, present in the retinitis pigmentosa GTPase regulator interacting protein 1 gene, was exposed to Gypenosides. The substance was sourced from Gynostemma pentaphyllum, a climbing vine, and previously found to combat oxidative stress and inflammation in optic neuritis cells.
The results suggest significant benefits from the application of Gypenosides to retinitis pigmentosa. Treatment of the mutated zebrafish resulted in a notable decrease in the death rate of photoreceptor cells. The reaction of antioxidant genes typically associated with oxidative stress was also significantly reduced. Furthermore, there were marked reductions in reactive oxygen species and malondialdehyde production, along with diminished expression of pro-inflammatory cytokines. Overall, the outcome indicates that Gypenosides effectively counteracted the harmful effects of the mutation, protecting the photoreceptors from degeneration.
